小發(fā)夾RNA

編輯這個(gè)頁(yè)面須要登錄或更高權(quán)限！

• 您剛才的請(qǐng)求只有這個(gè)用戶組的用戶才能使用：自動(dòng)確認(rèn)用戶
• 如果您還沒(méi)有登錄請(qǐng)登錄后重試。A+醫(yī)學(xué)百科是一個(gè)開(kāi)放式網(wǎng)站，修改本站大部分內(nèi)容僅須要花10秒鐘時(shí)間創(chuàng)建一個(gè)賬戶。 如果您已經(jīng)登錄，本頁(yè)面可能是受保護(hù)的內(nèi)容。如果您認(rèn)為有修改的必要，請(qǐng)聯(lián)系本站管理人員。

條目源代碼：

'''小發(fā)夾RNA'''（{{lang-en|'''short hairpin RNA'''}}，縮寫{{lang|en|'''shRNA'''}}）是一[[種形成]]急轉(zhuǎn)彎（hairpin turn）結(jié)構(gòu)的[[RNA]]序列，可以經(jīng)由RNA干擾（RNAi）使[[基因表現(xiàn)]][[基因沉默|沉默化]]。shRNA可利用載體導(dǎo)入[[細(xì)胞]]當(dāng)中，并借由U6[[啟動(dòng)子]]來(lái)確保shRNA的表現(xiàn)。另外，shRNA可經(jīng)由切割轉(zhuǎn)變成為siRNA == 參考文獻(xiàn) == {{Reflist|2}} * {{cite journal en |author = McIntyre G, Fanning G |title = Design and cloning strategies for constructing shRNA expression vectors |journal = BMC Biotechnol. |volume = 6 |issue = |pages = 1 |year = 2006 |url = http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=1343552 |pmid = 16396676}} * {{cite journal en |author = Harper S, Staber P, He X, Eliason S, Martins I, Mao Q, Yang L, Kotin R, Paulson H, Davidson B |title = RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model |journal = Proc. Natl. Acad. Sci. U.S.A. |volume = 102 |issue = 16 |pages = 5820-5 |year = 2005 |url = http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=556303 |pmid = 15811941}} * {{cite journal en |author = Nielsen M, Pedersen F, Kjems J |title = Molecular strategies to inhibit HIV-1 replication |journal = Retrovirology |volume = 2 |issue = |pages = 10 |year = 2005 |url = http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez&artid=553987 |pmid = 15715913}} * {{cite journal en |author = Paddison P, Caudy A, Bernstein E, Hannon G, Conklin D |title = Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells |journal = Genes Dev. |volume = 16 |issue = 8 |pages = 948-58 |year = 2002 |url = http://www.genesdev.org/cgi/content/full/16/8/948 |pmid = 11959843}} * {{cite journal en |author = Cao W, Hunter R, Strnatka D, McQueen C, Erickson R |title = DNA constructs designed to produce short hairpin, interfering RNAs in transgenic mice sometimes show early lethality and an interferon response |journal = J. Appl. Genet. |volume = 46 |issue = 2 |pages = 217-25 |year = 2005 |url = http://jag.igr.poznan.pl/2005-Volume-46/2/pdf/2005_Volume_46_2-217-225.pdf |pmid = 15876690}} == 參見(jiàn) == * [[RNA干擾]] {{-}} {{Nucleic acids}} [[Category:RNA]] [[Category:RNA干擾]] ==參考來(lái)源== *[http://zh.wikipedia.org/wiki/%E5%B0%8F%E9%AB%AE%E5%A4%BERNA 維基百科-小髮夾RNA]

返回到小發(fā)夾RNA。