促卵泡激素β亞基

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Follicle stimulating hormone, beta polypeptide
促卵泡激素，β多肽

PDB rendering based on 1fl7.
有效結(jié)構(gòu)
PDB 直系同源檢索：PDBe, RCSB
標(biāo)識(shí)
代號(hào) FSHB
擴(kuò)展標(biāo)識(shí) 遺傳學(xué)：136530 鼠基因：95582 同源基因：430 GeneCards: FSHB Gene
RNA表達(dá)模式
PBB GE FSHB 214489 at tn.png
更多表達(dá)數(shù)據(jù)
直系同源體
物種 人類(lèi) 鼠類(lèi)
Entrez 2488 14308
Ensembl ENSG00000131808 ENSMUSG00000027120
UniProt P01225 Q60687
mRNA序列 NM_000510 NM_008045
蛋白序列 NP_000501 NP_032071
基因位置 Chr 11:
30.25 – 30.26 Mb		 Chr 2:
107.06 – 107.06 Mb
PubMed查詢(xún) [1] [2]

促卵泡激素β亞基（英語(yǔ)：Follitropin subunit beta 或 follicle-stimulating hormone beta subunit 縮寫(xiě)FSH-B）是一種由人類(lèi)基因FSHB 編碼的蛋白質(zhì)[1][2][3] 。其RNA的選擇性剪接可形成該蛋白的兩種蛋白異型體。

目錄

功能

垂體糖蛋白激素家族包括促卵泡激素、黃體生成素、人絨毛膜促性腺激素和促甲狀腺激素，所有這些糖蛋白激素都包括一個(gè)共同的α亞基和一個(gè)特異的β亞基。FSHB 基因編碼的就是促卵泡激素的β亞基。 In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production.[3]

參考文獻(xiàn)

  1. ↑ Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. DNA. Aug 1987, 6 (3): 205–12. doi:10.1089/dna.1987.6.205. PMID 2885163. 
  2. ↑ Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN. A reevaluation of the amino acid sequence of human follitropin beta-subunit. J Protein Chem. Sep 1989, 7 (4): 325–39. doi:10.1007/BF01024882. PMID 3151250. 
  3. ↑ 3.0 3.1 Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide. 

延伸閱讀

  • Barrios-De-Tomasi J, Timossi C, Merchant H et al.. Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones. Mol. Cell. Endocrinol.. 2002, 186 (2): 189–98. doi:10.1016/S0303-7207(01)00657-8. PMID 11900895. 
  • Saxena BB, Rathnam P. Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands. J. Biol. Chem.. 1976, 251 (4): 993–1005. PMID 1249074. 
  • Keene JL, Matzuk MM, Otani T et al.. Expression of biologically active human follitropin in Chinese hamster ovary cells. J. Biol. Chem.. 1989, 264 (9): 4769–75. PMID 2494176. 
  • Jameson JL, Becker CB, Lindell CM, Habener JF. Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids. Mol. Endocrinol.. 1988, 2 (9): 806–15. doi:10.1210/mend-2-9-806. PMID 3139991. 
  • Shome B, Parlow AF. Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb). J. Clin. Endocrinol. Metab.. 1974, 39 (1): 203–5. doi:10.1210/jcem-39-1-203. PMID 4835136. 
  • Fujiki Y, Rathnam P, Saxena BB. Studies on the disulfide bonds in human pituitary follicle-stimulating hormone. Biochim. Biophys. Acta. 1980, 624 (2): 428–35. PMID 6774759. 
  • B?ckers TM, Nieschlag E, Kreutz MR, Bergmann M. Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men. Cell Tissue Res.. 1995, 278 (3): 595–600. doi:10.1007/BF00331379. PMID 7850869. 
  • Matthews CH, Borgato S, Beck-Peccoz P et al.. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat. Genet.. 1993, 5 (1): 83–6. doi:10.1038/ng0993-83. PMID 8220432. 
  • Layman LC, Lee EJ, Peak DB et al.. Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene. N. Engl. J. Med.. 1997, 337 (9): 607–11. doi:10.1056/NEJM199708283370905. PMID 9271483. 
  • Cargill M, Altshuler D, Ireland J et al.. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet.. 1999, 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 
  • Grasso P, Rozhavskaya-Arena M, Reichert LE. Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle. Regul. Pept.. 1999, 81 (1–3): 67–71. doi:10.1016/S0167-0115(99)00022-1. PMID 10395410. 
  • Ben-Menahem D, Hyde R, Pixley M et al.. Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation. Biochemistry. 1999, 38 (46): 15070–7. doi:10.1021/bi991510c. PMID 10563789. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC16267/ Shotgun sequencing of the human transcriptome with ORF expressed sequence tags]. Proc. Natl. Acad. Sci. U.S.A.. 2000, 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800. PMC 16267. 
  • Hartley JL, Temple GF, Brasch MA. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC310948/ DNA Cloning Using In Vitro Site-Specific Recombination]. Genome Res.. 2001, 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863. PMC 310948. 
  • Fox KM, Dias JA, Van Roey P. Three-dimensional structure of human follicle-stimulating hormone. Mol. Endocrinol.. 2001, 15 (3): 378–89. doi:10.1210/me.15.3.378. PMID 11222739. 
  • Amoresano A, Orrù S, Siciliano RA et al.. Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain. Biol. Chem.. 2002, 382 (6): 961–8. doi:10.1515/BC.2001.120. PMID 11501762. 
  • Walton WJ, Nguyen VT, Butnev VY et al.. Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit. J. Clin. Endocrinol. Metab.. 2001, 86 (8): 3675–85. doi:10.1210/jc.86.8.3675. PMID 11502795. 

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